Academic and Professional Qualifications

Education

• PhD in Chemistry (Peradeniya, SL)
• B.Sc special in Zoology (Hons.) (Ruhuna, SL)

Professional Experience

• Postdoctoral Fellow – Natural Product Chemistry | SLINTEC | 2024–2026
• Research and Development Unit | Nature’s Secret Pvt Ltd | 2021–2024

Professional Qualifications

• Successfully completed the Computer Literacy Course at the University of Ruhuna (2015).
• Successfully completed the Scientific Writing Course conducted by the Postgraduate Institute of Science, University of Peradeniya (2020).
• Completed the Immunology Training Course at the Institute of Biochemistry, Molecular Biology and Biotechnology(2026).

Contribution of Institutional and National Development

• Contributed to the development of “A Guide to Research Proposal Preparation and Evaluation in Science & Technology” introduced by the Ministry of Science and Technology in 2026.

Memberships and Activities in Professional Bodies

• Member of the resource pool of expertise for research review and roadmap development- (Ministry of Science and Technology) (2025-2027).
• Member of the Young Scientists Forum (YSF), National Science and Technology Commission (2021-present) (ID- Y/S/131).

Publications

Magazine

1. S.N.T.I. Sampath. (2026). NATURAL KILLER T (NKT) CELLS” THE DOUBLE AGENTS OF THE IMMUNE SYSTEM. Feature Articles of the “Science and Technology Letters” YSF E-Magazine, Young Scientists Forum, National Science and Technology Commission, Sri Lanka, 2026 – Vol. 1, 158p.ISBN 978-955-8630-48-8.

Journal Publications

1. Abesingha, A.K., Thennakoon, T., Sampath, T.I. and Jayasinghe, S. (2026). Comparative and correlation studies of garcinol content with in vitro alpha-amylase inhibitory activity, and antioxidant properties of fruits, leaves and bark extracts from two Sri Lankan endemic Garcinia species: Garcinia quaesita and Garcinia zeylanica. Journal of Herbs, Spices & Medicinal Plants. 1–19. https://doi.org/10.1080/10496475.2026.2663390.
2. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2026). A novel compound mixture mitigates hyperglycemia, insulin resistance, dyslipidemia, and oxidative stress in streptozotocin induced diabetic rats: A therapeutic drug lead for metabolic syndrome. Fitoterapia. 107091. https://doi.org/10.1016/j.fitote.2026.107091.
3. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2025). Acute and sub-acute toxicological evaluation of a bioactive compound mixture in healthy Wistar rats. Drug and Chemical Toxicology. 48(6): 1-12. https://doi.org/10.1080/01480545.2025.2565712.
4. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P., Karunaratne, Mahesh Loku Yaddehige V. V. and Davita L. Watkins (2022). A new dimeric carbazole alkaloid from Murraya koenigii (L.) leaves with Alpha-amylase and Alpha-glucosidase inhibitory activities. Phytochemistry Letters. 52: 87-91. DOI: https://doi.org/10.1016/j.phytol.2022.09.013.
5. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2021). Sub- acute antihyperlipidemic and antihyperglycemic activity of the hexane extract of a polyherbal mixture in streptozotocin-induced diabetic rats. Ceylon Journal of Science. 50(3): 279-287. DOI: http://doi.org/10.4038/cjs.v50i3.7909.
6. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2021). Antioxidant and Antidiabetic Potentials of a Standardized Polyherbal Mixture Used in Traditional Medicine. Jordan Journal of Chemistry. 17(1): 13-26. DOI: https://doi.org/10.47014/17.1.2.
7. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2026). A blend of Alpha-amylase and Alpha-glucosidase enzyme inhibitors from a known polyherbal mixture leads to enhanced synergistic potency. Pharmaceutical Chemistry. (Accepted on 13.07.2025).

Conference Publications

1. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2023). A compound mixture formulated from a traditional polyherbal mixture exerting a synergistic antidiabetic activity, Proceedings of the 7th International Conference on Medical & Health Sciences, Ordu University, Faculty of Medicine, Ordu, Turkiye. Pp. 1349.
2. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2022). Comparative in vitro antidiabetic activity of two amides from black pepper seeds (Piper nigrum l.) against postprandial glucose regulatory enzymes. Postgraduate Institute of Science Research Congress, Peradeniya, Sri Lanka. Pp. 161.
3. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2022). Chemical investigation on antidiabetic activity of garcinol isolated from Garcinia quaesita: Exploration through in vitro and in vivo antidiabetic mechanism. CUKUROVA 9th International Scientific Researches Conference, Adana, Turkey. Pp. 404.
4. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2022). Alpha- amylase and alpha-glucosidase inhibitory activities of a novel compound isolated from Murraya koenigii. International Conference on Applied and Pure Sciences, Faculty of Science, University of Kelaniya, Sri Lanka. Pp. 16.
5. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2022). Antidiabetic mechanisms of the hexane extract of an Ayurvedic polyherbal mixture in diabetic rats: A reflection on enzyme activities of antioxidant and carbohydrate metabolism pathways. Proceedings of 9th Ruhuna International Science & Technology Conference University of Ruhuna, Matara, Sri Lanka. Pp.14.
6. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2021). Homeostatic model assessment of a Sri Lankan polyherbal mixture in streptozotocin induced diabetic rats. 8th Ruhuna International Science and Technology Conference -2021. Faculty of Science, University of Ruhuna, Wellamadama, Matara, Sri Lanka. Pp. 103.
7. A.M.A.K. Abesingha, J.M.S. Jayasingha and S.N.T.I. Sampath (2021). In Vitro Antioxidant and Antihyperglycemic Activities of Plant Extracts of Garcinia zeylanica. Proceedings of the Postgraduate Institute of Science Research Congress, Peradeniya, Sri Lanka. Pp. 110.
8. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2021). Antihyperlipidamic activity of hexane extract of a polyherbal mixture in streptozotocin induced diabetic rats. 8th Annual Scientific Sessions & International Conference 2020/2021. Sri lanka association for laboratory animal science. Pp.31.
9. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2020). Investigation of antihyperglycaemic activity of hexane extract of polyherbal mixture in streptozotocin induced diabetic rats. International Conference on Applied and Pure Sciences, Faculty of Science, University of Kelaniya, Sri Lanka. Pp. 24.
10. K.J.W. Rajapaksa, J.M.S. Jayasingha and T. Sampath. (2020). Determination of bioactivity and isolation of garcinol in Garcinia quaesita. Proceedings of the Postgraduate Institute of Science Research Congress, Peradeniya, Sri Lanka. Pp. 133.
11. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2020). Evaluation of Physical Parameters and in-Vitro and in-Vivo Antidiabetic Activity of a Selected Combined Medicinal Plant Extracts Mixture, International Conference on Natural Products, London, United Kingdom. Vol:14, No:6, 2020.
12. Sampath, S.N.T.I., Jayasinghe, J.M.S., Attanayake, A.P. and Karunaratne, V. (2019). Phytochemical screening, acute hypoglycaemic and toxicity assessment of a selected combined medicinal plant extract mixture, Proceedings of the 2nd International Conference on Health Sciences, Faculty of Medical Science, University of Sri Jayewardenepura. Pp. 161.
13. Sampath, S.N.T.I., Jayasinghe, E.G.R.K. Somawardane, D.S.N.K. Liyanagamage, J.M.S., Attanayake, A.P. and Karunaratne, V. (2018). Antioxidant activity of a selected combined medicinal plant mixture and its’ corresponding individual plants, Asian Symposium on Medicinal Plants Species and Other Natural Products XVI, Colombo, Sri Lanka. Pp. 136.
14. Sampath, S.N.T.I., De Silva, M.P.K.S.K., (2018). Growth and Colour Enhancement of Masculinized Red Blonde Guppy Fish (Poecilia reticulata) Using Animal and Plant Disposals as Dietary Supplements, Proceedings of the 24th scientific sessions of the Sri Lanka Association for Fisheries and Aquatic Resources (SLAFAR), Faculty of Social Sciences, University of Kelaniya Pp. 11.
15. Sampath, S.N.T.I., De Silva, M.P.K.S.K., (2017). Colour Enhancement of Masculinized Guppy Fish (Poecilia reticulata), Proceedings of 2nd Research Undergraduate Symposium, Faculty of Science, University of Ruhuna Pp. 08.
16. Sampath, S.N.T.I., De Silva, M.P.K.S.K., (2017). Effect of methyltestosterone treated feed on growth and gonadal histology of red blonde guppy fish (Poecilia reticulata), Proceedings of 2nd International Research Symposium, Faculty of Science, University of Uwa Wellassa Pp. 63.
17. K.D.Madhushani, M.A.L.Dammika, W.K.S.Premarathne, N.K.Wijerama, D.D.S.Dissanayake, N.M.Ellepola, H.V.S.Baratha, A.M.K.C.J.Costa, S.S.Williams & S.N.T.I. Sampath, (2015). A survey on life style and farming practices of farmers in “Sooriyawewa” area, Proceedings of 1st Research Undergraduate Symposium, Faculty of Science, University of Ruhuna Pp. 22.

Book Chapter

1. T.D.G. Liyanage and S.N.T.I. Sampath (2026). Emerging Horizons of Nanomedicine in Drug Discovery and Development. In Contemporary Biotechnology in Health and Medicine. © Halic Publishers 2025. ISBN: 978-625-93102-1-3. DOI: 10.5281/zenodo.18304841. 55-86.

Research Interests

• Biomedical applications of natural products
• Bioactive compound isolation and characterization, in vivo and in vitro studies
• Herbal Standardization
• Medicinal Plant Bioactivity
• Zoology
• Natural product chemistry